Single-cell multiplex approaches deeply map ON-target CRISPR-genotoxicity and reveal its mitigation by palbociclib and long-term engraftment
Julian Boutin, Sabrina Fayet, V Terribile Wiel Marin, Camille Bergès, Maude Riandière, Jérôme Toutain, Isabelle Lamrissi‐Garcia, Chloé Thibault, David Cappellen, Sandrine Dabernat, Arthur Poulet, M. Francillette, Nathalie M Droin, Christelle Debeissat, Philippe Brunet de la Grange, , Aurélie Bedel
The paper develops a multiplexed single-cell approach to monitor CRISPR-induced genotoxicity and shows that palbociclib reduces genomic rearrangements in hematopoietic cells.
Nature Communications · Jan 10, 2026Peer-reviewedBioengineering