Error-prone bypass of DNA lesions during lagging strand replication is a common source of germline and cancer mutations
V. Seplyarskiy, E. E. Akkuratov, N. V. Akkuratova, M. A. Andrianova, S. I. Nikolaev, G. A. Bazykin, I. Adameyko, S. R. Sunyaev
The paper identifies error-prone bypass of DNA lesions on the lagging strand as a major source of human germline and cancer mutations, supported by mutational asymmetry analysis and experimental validation.
bioRxiv · May 26, 2018Biochemistry