Author

M. A. Aslam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

E. de Wit· 2 shared E. M. Kwesi-Maliepaard· 2 shared F. van Leeuwen· 2 shared H. Jacobs· 2 shared M. F. Alemdehy· 2 shared T. van den Brand· 2 shared T. van Welsem· 2 shared C. Lancini· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

E. de Wit

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Histone methyltransferase DOT1L controls state-specific identity during B cell differentiation

M. A. Aslam, M. F. Alemdehy, E. M. Kwesi-Maliepaard, M. Caganova, I. N. Pardieck, T. van den Brand, F. I. Muhaimi, T. van Welsem, I. de Rink, J.-Y. Song, E. de Wit, R. Arens, K. Rajewsky, H. Jacobs, F. van Leeuwen

This study identifies DOT1L as a key regulator of B cell differentiation by controlling epigenetic programs that maintain B cell naivety and support germinal center formation.

bioRxiv · Mar 25, 2020Immunology

The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8+ T cells

E. M. Kwesi-Maliepaard, M. A. Aslam, M. F. Alemdehy, T. van den Brand, C. McLean, H. Vlaming, T. van Welsem, T. Korthout, C. Lancini, S. Hendriks, T. Ahrends, D. van Dinther, J. M. den Haan, J. Borst, E. de Wit, , H. Jacobs

This study shows that DOT1L prevents premature differentiation of CD8+ T cells and maintains their epigenetic identity, independent of antigen exposure.

bioRxiv · Nov 18, 2019Immunology