Author

F. van Leeuwen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Research Focus:chromatin & epigenetic regulation· 4 Organism:mouse· 4 Assay:ChIP-seq· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

E. M. Kwesi-Maliepaard· 3 shared H. Jacobs· 3 shared M. F. Alemdehy· 3 shared C. Lancini· 2 shared C. McLean· 2 shared E. de Wit· 2 shared H. Vlaming· 2 shared M. A. Aslam· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersImmunology

E. M. Kwesi-Maliepaard

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Enhancer plasticity in endometrial tumorigenesis demarcates non-coding somatic mutations and 3D-genome alterations boosting the oncogenic driver ESR1

S. Gregoricchio, A. Kojic, M. Hoogstraat, K. Schuurman, S. Stelloo, T. M. Severson, T. A. O'Mara, M. Droog, A. A. Singh, D. M. Glubb, L. F. A. Wessels, M. Vermeulen, F. van Leeuwen, W. Zwart

The paper identifies enhancer plasticity and 3D-genome alterations in endometrial cancer that boost ESR1 expression through non-coding mutations and risk variants.

bioRxiv · Jul 25, 2023Cancer Biology

SETD2 negatively regulates cell size through its catalytic activity and SRI domain

T. M. Molenaar, E. M. Kwesi-Maliepaard, J. Silva, M. Malik, W. J. Faller, F. van Leeuwen

This study identifies SETD2 as a negative regulator of cell size through its catalytic activity, independent of H3K36 methylation, and shows that its SRI domain interacts with non-histone substrates to modulate protein synthesis.

bioRxiv · Oct 31, 2021Cell Biology

The helminth glycoprotein omega-1 improves metabolic homeostasis in obese mice through type-2 immunity-independent inhibition of food intake

H. J. P. van der Zande, M. A. Gonzalez, K. de Ruiter, R. Wilbers, N. Garcia-Tardon, M. van Huizen, K. van Noort, L. R. Pelgrom, J. M. Lambooij, A. Zawistowska-Deniziak, F. Otto, A. Ozir-Fazalalikhan, D. van Willigen, M. Welling, J. Poles, , B. Guigas

This paper shows that the helminth glycoprotein omega-1 improves metabolic health in obese mice by reducing food intake, independent of type 2 immunity.

bioRxiv · Jul 3, 2020Immunology

Histone methyltransferase DOT1L controls state-specific identity during B cell differentiation

M. A. Aslam, M. F. Alemdehy, E. M. Kwesi-Maliepaard, M. Caganova, I. N. Pardieck, T. van den Brand, F. I. Muhaimi, T. van Welsem, I. de Rink, J.-Y. Song, E. de Wit, R. Arens, K. Rajewsky, H. Jacobs, F. van Leeuwen

This study identifies DOT1L as a key regulator of B cell differentiation by controlling epigenetic programs that maintain B cell naivety and support germinal center formation.

bioRxiv · Mar 25, 2020Immunology

The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8+ T cells

E. M. Kwesi-Maliepaard, M. A. Aslam, M. F. Alemdehy, T. van den Brand, C. McLean, H. Vlaming, T. van Welsem, T. Korthout, C. Lancini, S. Hendriks, T. Ahrends, D. van Dinther, J. M. den Haan, J. Borst, E. de Wit, , H. Jacobs

This study shows that DOT1L prevents premature differentiation of CD8+ T cells and maintains their epigenetic identity, independent of antigen exposure.

bioRxiv · Nov 18, 2019Immunology

Evolutionarily-conserved chromatin crosstalk generates a DOT1L-dose dependency in thymic lymphoma caused by loss of HDAC1

H. Vlaming, C. McLean, T. Korthout, M. F. Alemdehy, S. Henriks, C. Lancini, S. Palit, S. Klarenbeek, T. M. Molenaar, L. Hoekman, T. T. Schmidlin, M. Altelaar, T. v. Welsem, J.-H. Dannenberg, H. Jacobs, F. van Leeuwen

The paper identifies an evolutionarily-conserved interaction between HDAC1 and DOT1L that influences H3K79 methylation and contributes to thymic lymphoma development.

bioRxiv · Jan 10, 2019Cell Biology