K. Rajewsky

A new type of transcriptional reprogramming by an IRF4 mutation in lymphoma

This study identifies a mutation in IRF4 that alters DNA-binding specificity and gene regulation in lymphoma, leading to disease-specific gene up-regulation.

B cells are addicted to immunoglobulin production in the ER

The paper shows that B cells rely on ER-resident immunoglobulin heavy chains for ER homeostasis and mitochondrial function, independent of BCR signaling.

Preclinical models of human multiple myeloma subgroups

This study generates preclinical models of human multiple myeloma subgroups by inducing specific genetic alterations in mice, showing their resemblance to human disease.

Co-activation of NF-κB and MYC renders cancer cells addicted to IL6 for survival and phenotypic stability

This paper shows that co-activation of NF-κB and MYC in cancer cells makes them dependent on IL6 for survival and leads to a poorly-differentiated state similar to human plasmablastic lymphoma and t(8;14)[MYC-IGH] multiple myeloma.

Histone methyltransferase DOT1L controls state-specific identity during B cell differentiation

This study identifies DOT1L as a key regulator of B cell differentiation by controlling epigenetic programs that maintain B cell naivety and support germinal center formation.

B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage

This study shows that B-1a cells bypass the pre-BCR selection stage by developing in fetal liver with reduced IL-7R/STAT5 levels, leading to self-reactive BCRs.