Author

M. A. Brehm

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:imaging· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. Lipfert· 2 shared M. Benoit· 2 shared T. Obser· 2 shared A. Hausch· 1 shared A. Loef· 1 shared A. Löf· 1 shared A. Seth· 1 shared B. Kiss· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiophysics

J. Lipfert

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Author profile →

4 papers

Recent·Most cited

Minimization of metabolic cost of transport predicts changes in gait mechanics over a range of ankle-foot orthosis stiffnesses in individuals with bilateral plantar flexor weakness

B. Kiss, N. F. J. Waterval, M. M. van der Krogt, M. A. Brehm, T. Geijtenbeek, J. Harlaar, A. Seth

This study uses simulations to show that minimizing metabolic cost of transport predicts gait adaptations to varying ankle-foot orthosis stiffness in individuals with plantar flexor weakness.

Frontiers in Bioengineering and Biotechnology · May 23, 2024Peer-reviewedBioengineering

A human immune/muscle xenograft model of FSHD muscle pathology

K. Daman, J. Yan, L. M. Burzenski, J. Kady, L. D. Shultz, M. A. Brehm, C. P. Emerson

This study develops a humanized mouse model to investigate the role of innate immunity in FSHD muscle pathology and identifies immune cell accumulation and complement gene expression in FSHD muscle xenografts.

bioRxiv · Nov 17, 2023 · PreprintImmunology

A Conformational Transition of Von Willebrand Factor's D'D3 Domain Primes It For Multimerization

S. Gruber, A. Loef, A. Hausch, R. Joehr, T. Obser, G. Koenig, R. Schneppenheim, M. A. Brehm, M. Benoit, J. Lipfert

This study uses single-molecule force spectroscopy to show that a conformational change in VWF's DD3 domain, triggered by pH changes and stabilized by FVIII, primes it for multimerization.

bioRxiv · Nov 29, 2021 · PreprintBiophysics

Modular, ultra-stable, and highly parallel protein force spectroscopy in magnetic tweezers using peptide linkers

A. Löf, P. U. Walker, S. M. Sedlak, T. Obser, M. A. Brehm, M. Benoit, J. Lipfert

This paper introduces a modular magnetic tweezers approach using peptide linkers to enable ultra-stable, parallel protein force spectroscopy in the low force regime, revealing new insights into protein unfolding and activation mechanisms.

bioRxiv · Dec 10, 2018Biophysics