Author

T. Obser

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:protein structure· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

J. Lipfert· 2 shared M. A. Brehm· 2 shared M. Benoit· 2 shared A. Hausch· 1 shared A. Loef· 1 shared A. Löf· 1 shared G. Koenig· 1 shared P. U. Walker· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersBiophysics

J. Lipfert

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2 papers

Recent·Most cited

A Conformational Transition of Von Willebrand Factor's D'D3 Domain Primes It For Multimerization

S. Gruber, A. Loef, A. Hausch, R. Joehr, T. Obser, G. Koenig, R. Schneppenheim, M. A. Brehm, M. Benoit, J. Lipfert

This study uses single-molecule force spectroscopy to show that a conformational change in VWF's DD3 domain, triggered by pH changes and stabilized by FVIII, primes it for multimerization.

bioRxiv · Nov 29, 2021 · PreprintBiophysics

Modular, ultra-stable, and highly parallel protein force spectroscopy in magnetic tweezers using peptide linkers

A. Löf, P. U. Walker, S. M. Sedlak, T. Obser, M. A. Brehm, M. Benoit, J. Lipfert

This paper introduces a modular magnetic tweezers approach using peptide linkers to enable ultra-stable, parallel protein force spectroscopy in the low force regime, revealing new insights into protein unfolding and activation mechanisms.

bioRxiv · Dec 10, 2018Biophysics