Author

M. A. Cahill

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 4 Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Assay:DNA methylation· 2 Organism:mouse· 2 Assay:proteomics· 2

Frequent Co-Authors

B. M. Thejer· 2 shared D. Aragao· 2 shared E. J. New· 2 shared E. M. Goldys· 2 shared H. Neubauer· 2 shared J. A. Jazayeri· 2 shared J. K. Forwood· 2 shared L. A. Weston· 2 shared

Activity by Year

2019-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCell Biology

B. M. Thejer

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Author profile →

5 papers

Recent·Most cited

Structural characterization of a MAPR-related archaeal cytochrome b5M protein

S. Teakel, M. Marama, D. Aragao, S. Tsimbalyuk, J. K. Forwood, M. A. Cahill

The paper presents a second crystal structure of an archaeal cytb5M domain, supporting the hypothesis that MAPR-like heme orientation originated from prokaryotic ancestors.

bioRxiv · Nov 30, 2021 · PreprintBiochemistry

MAPR origins reveal a new class of prokaryotic cytochrome b5 proteins and possible role in eukaryogenesis

D. Tamarit, S. Teakel, M. Marama, D. Aragao, S. Y. Gerdes, J. K. Forwood, T. J. G. Ettema, M. A. Cahill

The paper identifies a new class of prokaryotic cytochrome b5 proteins related to eukaryotic MAPR family members and suggests a bacterial origin for PGRMC1 and CYP51A.

bioRxiv · Nov 17, 2021 · PreprintEvolutionary Biology

PGRMC1 phosphorylation and cell plasticity 2: genomic integrity and CpG methylation

B. M. Thejer, P. P. Adhikary, S. L. Teakel, J. Fang, P. A. Weston, S. Gurusinghe, A. G. Anwer, M. Gosnell, J. A. Jazayeri, M. Ludescher, L.-A. Gray, M. Pawlak, R. H. Wallace, S. D. Pant, M. Wong, , M. A. Cahill

This study shows that PGRMC1 phosphorylation mutants alter genomic stability, CpG methylation, and cell metabolism, suggesting a role in cellular plasticity and tissue differentiation.

bioRxiv · Sep 18, 2019Cell Biology

PGRMC1 phosphorylation and cell plasticity 1: glycolysis, mitochondria, tumor growth

B. M. Thejer, P. P. Adhikary, A. Kaur, S. L. Teakel, A. Van Oosterum, I. Seth, M. Pajic, K. M. Hannan, M. Pavy, P. Poh, J. A. Jazayeri, T. Zaw, D. Pascovici, M. Ludescher, M. Pawlak, , M. A. Cahill

This study shows that altering PGRMC1 phosphorylation in cancer cells affects energy metabolism, mitochondrial function, and tumor growth.

bioRxiv · Sep 6, 2019Cancer Biology

Early eukaryotic origins and metazoan elaboration of MAPR family proteins

E. Hehenberger, M. Eitel, S. A. V. Fortunato, D. J. Miller, P. J. Keeling, M. A. Cahill

This paper traces the evolutionary origins of MAPR family proteins, showing their presence in the common ancestor of Opisthokonta and their functional diversification in animals.

bioRxiv · Aug 20, 2019Evolutionary Biology