Author

M. Pawlak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2

Frequent Co-Authors

B. M. Thejer· 2 shared E. J. New· 2 shared E. M. Goldys· 2 shared H. Neubauer· 2 shared J. A. Jazayeri· 2 shared L. A. Weston· 2 shared M. A. Cahill· 2 shared M. Ludescher· 2 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

B. M. Thejer

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A platform of patient-derived microtumors identifies therapeutic vulnerabilities in ovarian cancer.

N. Anderle, A. Koch, B. Gierke, A.-L. Keller, A. Staebler, A. Hartkopf, S. Brucker, M. Pawlak, K. Schenke-Layland, C. Schmees

This paper develops a 3D patient-derived microtumor platform to identify therapeutic vulnerabilities in ovarian cancer by testing drug responses and immune cell interactions.

bioRxiv · Nov 10, 2021 · PreprintCancer Biology

Induction of a colitogenic phenotype in Th1 cells depends on IL-23R signaling

M. Pawlak, D. DeTomaso, G. Meyer zu Horste, Y. Lee, J. Nyman, D. Dionne, C. Wang, A. Wallrapp, P. R. Burkett, S. J. Riesenfeld, A. C. Anderson, A. Regev, R. J. Xavier, N. Yosef, V. K. Kuchroo

This study shows IL-23R signaling enables Th1 cells to acquire a colitogenic phenotype, distinct from Th17 cells, and identifies CD160 as a key regulator.

bioRxiv · Jan 24, 2021 · PreprintImmunology

Antinociceptive modulation by the adhesion-GPCR CIRL promotes mechanosensory signal discrimination

S. Dannhäuser, T. J. Lux, C. Hu, M. Selcho, J. Tsung-Chieh Chen, N. Ehmann, D. Sachidanandan, M. Pawlak, T. Langenhan, P. Soba, H. Rittner, R. J. Kittel

This study shows that CIRL modulates mechanosensory signals differently in low-threshold mechanoreceptors and high-threshold nociceptors, aiding in signal discrimination.

bioRxiv · Feb 24, 2020Physiology

PGRMC1 phosphorylation and cell plasticity 2: genomic integrity and CpG methylation

B. M. Thejer, P. P. Adhikary, S. L. Teakel, J. Fang, P. A. Weston, S. Gurusinghe, A. G. Anwer, M. Gosnell, J. A. Jazayeri, M. Ludescher, L.-A. Gray, M. Pawlak, R. H. Wallace, S. D. Pant, M. Wong, , M. A. Cahill

This study shows that PGRMC1 phosphorylation mutants alter genomic stability, CpG methylation, and cell metabolism, suggesting a role in cellular plasticity and tissue differentiation.

bioRxiv · Sep 18, 2019Cell Biology

PGRMC1 phosphorylation and cell plasticity 1: glycolysis, mitochondria, tumor growth

B. M. Thejer, P. P. Adhikary, A. Kaur, S. L. Teakel, A. Van Oosterum, I. Seth, M. Pajic, K. M. Hannan, M. Pavy, P. Poh, J. A. Jazayeri, T. Zaw, D. Pascovici, M. Ludescher, M. Pawlak, , M. A. Cahill

This study shows that altering PGRMC1 phosphorylation in cancer cells affects energy metabolism, mitochondrial function, and tumor growth.

bioRxiv · Sep 6, 2019Cancer Biology