H. Neubauer

Development of a Bipyrimidineamide based α-Helix Mimetic Lead Compound for efficient Targeting of MDM2 in Triple-Negative Breast Cancer

This study develops a bipyrimidineamide-based α-helix mimetic compound, VWK603, which effectively targets MDM2 in TNBC cells with lower toxicity than Nutlin-3a.

Lysosomal acid lipase-activity as a novel target to efficiently address triple-negative breast cancer high malignancy

This study shows that inhibiting lysosomal acid lipase (LIPA) reduces breast cancer stemness and sensitizes triple-negative breast cancer (TNBC) cells to chemotherapy, suggesting LIPA as a novel therapeutic target.

DanioCTC: Injection of circulating tumor cells from metastatic breast cancer patients in zebrafish xenografts for analysis of metastasis

DanioCTC injects patient-derived CTCs into zebrafish embryos to study metastasis, showing distinct dissemination patterns compared to cell line controls.

Establishment of a publicly available core genome multilocus sequence typing scheme for Clostridium perfringens

This paper establishes a core genome MLST scheme for C. perfringens and applies it to poultry and non-poultry strains to identify clustering patterns and associations with netB gene carriage and clinical disease.

GLS-driven glutamine catabolism contributes to prostate cancer radiosensitivity by regulating the redox state, stemness and ATG5-mediated autophagy

This study shows that glutamine catabolism via GLS regulates redox state, stemness, and autophagy in prostate cancer, affecting radiosensitivity and patient outcomes.

PGRMC1 phosphorylation and cell plasticity 2: genomic integrity and CpG methylation

This study shows that PGRMC1 phosphorylation mutants alter genomic stability, CpG methylation, and cell metabolism, suggesting a role in cellular plasticity and tissue differentiation.

PGRMC1 phosphorylation and cell plasticity 1: glycolysis, mitochondria, tumor growth

This study shows that altering PGRMC1 phosphorylation in cancer cells affects energy metabolism, mitochondrial function, and tumor growth.

The neonatal microenvironment programs conventional and intestinal Tbet+ γδT17 cells through the transcription factor STAT5

This study shows STAT5 is critical for neonatal expansion of γδT17 cells, which acquire tissue-specific traits necessary for immunity and autoimmunity.