M. A. Carlson

Selective epithelial expression of KRASG12D mutation drives ductal pancreatic neoplasia in Oncopigs

This study uses an Oncopig model to show that selective KRASG12D mutation in pancreatic epithelial cells drives neoplasia and stromal changes similar to human PDAC.

Ectopic expression of KRASG12D and p53R167H in porcine mammary epithelial cells results in transformation and tumorigenesis

This study generates tumorigenic porcine mammary epithelial cell lines by expressing KRASG12D and p53R167H, showing their ability to form tumors in mice.

Isolating and Cryo-Preserving Pig Skin Cells for Single Cell RNA Sequencing Study

This study develops a method for isolating and cryo-preserving pig skin cells for scRNA-Seq, enabling the identification of major skin cell types.

Porcine pancreatic ductal epithelial cells transformed with KRASG12D and SV40T are tumorigenic

This study generates a tumorigenic porcine pancreatic cell line using KRASG12D and SV40T and demonstrates its ability to form tumors in mice.

The effect of pre-resection obesity on post-resection body composition after 75% small bowel resection in rats

This study investigates whether pre-resection obesity protects against lean mass loss after massive small bowel resection in rats, finding no such protective effect.

Induction of pancreatic neoplasia in the KRAS/TP53 Oncopig

This study induces and characterizes pancreatic tumors in Oncopigs to create a large animal model of pancreatic cancer with molecular features similar to human disease.

Three-Dimensional (3D) Fibronectin Nano-Array Presented on Fibrin Matrix Accelerates Mice Skin Wound Healing

This study shows that a 3D fibronectin nano-array on a fibrin matrix accelerates mouse skin wound healing by enhancing cell adhesion, proliferation, and vascular morphogenesis.

Collateral development and arteriogenesis in hindlimbs of domestic swine after ligation of arterial inflow

This study examines collateral pathway development and arteriogenesis in swine hindlimbs after arterial ligation, finding increased vessel diameters and distinct collateral patterns based on ligation protocol.