M. A. Hollingsworth

This study shows DHODH inhibition enhances immune checkpoint blockade by increasing cancer cell antigen presentation through pyrimidine depletion and P-TEFb-mediated RNA polymerase II elongation.

This study generates a tumorigenic porcine pancreatic cell line using KRASG12D and SV40T and demonstrates its ability to form tumors in mice.

This study induces and characterizes pancreatic tumors in Oncopigs to create a large animal model of pancreatic cancer with molecular features similar to human disease.