Ligand-induced transmembrane conformational coupling in monomeric EGFR
S. Srinivasan, R. Regmi, X. Lin, C. A. Dreyer, X. Chen, S. D. Quinn, W. He, K. L. Carraway, M. A. Coleman, B. Zhang, G. S. Schlau-Cohen
This study shows ligand binding causes intracellular conformational changes in monomeric EGFR, linking extracellular and intracellular regions through the transmembrane helix.
bioRxiv · Oct 28, 2021Biophysics