Author

K. L. Carraway

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. L. Berg· 1 shared B. Zhang· 1 shared C. A. Dreyer· 1 shared C. Dreyer· 1 shared E. O'Donnell· 1 shared G. R. Bell· 1 shared G. S. Schlau-Cohen· 1 shared H. Lee· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperCancer Biology

A. L. Berg

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Structure-Activity Relationship Study Identifies a Novel Lipophilic Amiloride Derivative that Efficiently Kills Chemoresistant Breast Cancer Cells

M. Hu, R. Liu, N. Castro, L. Loza Sanchez, J. Learn, R. Huang, K. S. Lam, K. L. Carraway

This study identifies a novel amiloride derivative, LLC1, that shows potent cytotoxicity against chemoresistant breast cancer cell lines but limited efficacy in a metastatic mouse model.

bioRxiv · May 25, 2023 · PreprintPharmacology & Toxicology

Genetic Screen in a Pre-Clinical Model of High-Grade Complex Karyotype Sarcoma Characterizes Drivers of Distinct Sarcoma Subtypes and Identifies New Therapeutic Vulnerabilities

M. A. Munoz, J. Freeland, E. O'Donnell, J. Langerman, J. Bergonio, J. Surarez-Navarro, M. Darrow, S. Thorpe, R. Randall, K. L. Carraway, O. Witte, T. Graeber, J. Carr-Ascher

This paper develops a pre-clinical model of high-grade complex karyotype sarcomas to identify subtype-specific drivers and therapeutic targets through genetic screening and transcriptomic analysis.

bioRxiv · Jun 13, 2022 · PreprintCancer Biology

Wnt/PCP signaling mediates breast cancer metastasis by promoting pro-invasive protrusion formation in collectively motile leader cells

K. VanderVorst, C. Dreyer, J. Hatakeyama, G. R. Bell, A. L. Berg, M. Hernandez, H. Lee, S. R. Collins, K. L. Carraway

This study shows Wnt/PCP signaling promotes breast cancer metastasis by enhancing pro-invasive protrusions in leader cells during collective migration.

bioRxiv · Jan 7, 2022 · PreprintCancer Biology

Ligand-induced transmembrane conformational coupling in monomeric EGFR

S. Srinivasan, R. Regmi, X. Lin, C. A. Dreyer, X. Chen, S. D. Quinn, W. He, K. L. Carraway, M. A. Coleman, B. Zhang, G. S. Schlau-Cohen

This study shows ligand binding causes intracellular conformational changes in monomeric EGFR, linking extracellular and intracellular regions through the transmembrane helix.

bioRxiv · Oct 28, 2021Biophysics