Author

C. A. Dreyer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:fluorescence / live-cell microscopy· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

A. Prahallad· 1 shared A. Ruiz-Saenz· 1 shared B. Hann· 1 shared B. Pan· 1 shared B. Zhang· 1 shared C. Cowdrey· 1 shared C. E. Atreya· 1 shared C. Moelders· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperCancer Biology

A. Prahallad

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Author profile →

2 papers

Recent·Most cited

A reversible SRC-relayed COX2-inflammatory program drives therapeutic resistance in BRAF(V600E) colorectal tumors

A. Ruiz-Saenz, C. E. Atreya, C. Wang, B. Pan, C. A. Dreyer, D. Brunen, A. Prahallad, D. P. Munoz, D. J. Ramms, V. Burghi, D. S. Spassov, E. Fewings, Y. C. Hwang, C. Cowdrey, C. Moelders, , J.-P. Coppe

This study identifies a SRC-relayed COX2-inflammatory program that drives resistance to BRAF/MEK/EGFR therapies in BRAFV600E colorectal tumors and shows that co-targeting COX2 improves therapeutic outcomes.

bioRxiv · Oct 20, 2022 · PreprintCancer Biology

Ligand-induced transmembrane conformational coupling in monomeric EGFR

S. Srinivasan, R. Regmi, X. Lin, C. A. Dreyer, X. Chen, S. D. Quinn, W. He, K. L. Carraway, M. A. Coleman, B. Zhang, G. S. Schlau-Cohen

This study shows ligand binding causes intracellular conformational changes in monomeric EGFR, linking extracellular and intracellular regions through the transmembrane helix.

bioRxiv · Oct 28, 2021Biophysics