Author

M. A. Shammas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:whole-genome sequencing· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

C. Chakraborty· 3 shared C. Liao· 3 shared J. Shi· 3 shared J. Zhao· 3 shared M. K. Samur· 3 shared N. C. MUNSHI· 3 shared S. KUMAR· 3 shared S. Talluri· 3 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

C. Chakraborty

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3 papers

Recent·Most cited

ABL1 Kinase plays an important role in spontaneous and chemotherapy-induced genomic instability in multiple myeloma

S. KUMAR, S. Talluri, J. Zhao, C. Liao, L. B. Potluri, L. Buon, S. Mu, J. Shi, C. Chakraborty, Y.-T. Tai, M. K. Samur, M. A. Shammas, N. C. MUNSHI

This study shows that inhibiting ABL1 kinase reduces genomic instability and enhances the efficacy of chemotherapy in multiple myeloma.

bioRxiv · May 12, 2022Cancer Biology

Apurinic/apyrimidinic nuclease 1 drives genomic evolution contributing to chemoresistance and tumorigenesis in solid tumor

S. Kumar, J. Zhao, S. Talluri, L. Leutz Buon, S. Mu, B. Potluri, C. Liao, J. Shi, C. Chakraborty, G. B. Gonzalez, Y.-T. Tai, J. Patel, J. Pal, H. Mashimo, M. K. Samur, , M. A. Shammas

This study identifies APE1 as a driver of genomic instability in solid tumors, showing its role in chemoresistance and tumorigenesis through effects on DNA repair and genome stability.

bioRxiv · Apr 20, 2022 · PreprintCancer Biology

Integrated genomics and comprehensive validation reveal novel drivers of genomic evolution in esophageal adenocarcinoma

s. kumar, L. Buon, S. Talluri, M. Roncador, C. Liao, J. Zhao, J. Shi, C. Chakraborty, G. B. Gonzalez, Y.-T. Tai, R. Prabhala, M. K. Samur, N. C. Munshi, M. A. Shammas

The paper identifies a genomic instability gene signature linked to poor survival in esophageal adenocarcinoma and validates its role in tumor growth and genomic instability.

bioRxiv · Apr 23, 2020Cancer Biology