Y.-T. Tai

Spatial profiling of ovarian clear cell carcinoma reveals immune-hot features

This study uses spatial profiling to identify immune-hot features in early-stage ovarian clear cell carcinoma that correlate with recurrence.

ABL1 Kinase plays an important role in spontaneous and chemotherapy-induced genomic instability in multiple myeloma

This study shows that inhibiting ABL1 kinase reduces genomic instability and enhances the efficacy of chemotherapy in multiple myeloma.

Apurinic/apyrimidinic nuclease 1 drives genomic evolution contributing to chemoresistance and tumorigenesis in solid tumor

This study identifies APE1 as a driver of genomic instability in solid tumors, showing its role in chemoresistance and tumorigenesis through effects on DNA repair and genome stability.

Genetic Subtypes of Smoldering Multiple Myeloma are associated with Distinct Pathogenic Phenotypes and Clinical Outcomes

This study identifies six genetic subtypes of smoldering multiple myeloma associated with distinct clinical outcomes and progression risks.

Long Noncoding RNA RROL Provides Chromatin Scaffold for MYC-WDR82 Interaction to Impact Lipid Metabolism and Tumor Cell Growth in Multiple Myeloma

This study identifies RROL as a therapeutically actionable lncRNA in multiple myeloma that supports tumor growth through chromatin scaffolding of MYC-WDR82 interaction.

Case study: Digital spatial profiling of metastatic clear cell carcinoma reveals intra-tumor heterogeneity in epithelial-mesenchymal gradient.

This study uses spatial profiling to show an epithelial-mesenchymal gradient in metastatic OCCC but not in the primary tumor, revealing intermediate cell states.

Integrated genomics and comprehensive validation reveal novel drivers of genomic evolution in esophageal adenocarcinoma

The paper identifies a genomic instability gene signature linked to poor survival in esophageal adenocarcinoma and validates its role in tumor growth and genomic instability.