L. Diaz

Membrane Lipids Augment Cell Envelope Stress Signaling and Resistance to Antibiotics and Antimicrobial Peptides in Enterococcus faecalis

This study identifies the MadRS system and its operon madEFG as mediators of resistance to antimicrobial peptides and antibiotics in Enterococcus faecalis, linking membrane lipid changes to stress response and virulence.

Heavy Metal Pollution From a Major Earthquake and Tsunami in Chile Is Associated With Geographic Divergence of Clinical Isolates of Methicillin-Resistant Staphylococcus aureus in Latin America

This study links heavy-metal pollution from a Chilean earthquake and tsunami to the geographic spread of MRSA clones in Latin America.

Dynamics of the MRSA Population in A Chilean Hospital: A Phylogenomic Analysis (2000-2016)

This study analyzes MRSA clonal dynamics in a Chilean hospital from 2000-2016, finding increased diversity and the emergence of new clones replacing the dominant ChC clone.

Are Deep Learning Structural Models Sufficiently Accurate for Virtual Screening? Application of Docking Algorithms to AlphaFold2 Predicted Structures

This study evaluates the accuracy of AlphaFold2 structures for virtual screening, finding that out-of-the-box models are insufficient for hit-finding in low sequence identity targets and suggest post-processing improvements.

Are Deep Learning Structural Models Sufficiently Accurate for Free Energy Calculations? Application of FEP+ to AlphaFold2 Predicted Structures

The paper assesses if AlphaFold2 structures are accurate enough for FEP calculations in drug discovery, finding they perform comparably to X-ray structures in most cases.

Sequential development of embryoblast-like memory entities in human cancer tissues: An evolutionary self-repair structure with pluripotentiality

The paper identifies embryoblast-like memory entities in human cancer tissues that exhibit pluripotentiality and self-repair capabilities, suggesting potential for regenerative medicine and targeted therapies.

Genomic epidemiology of vancomycin resistant Enterococcus faecium (VREfm) in Latin America: Revisiting the global VRE population structure

This study characterizes the genomic structure of VREfm in Latin America and reconstructs the global population structure, revealing two main clinical clades and recombination-driven evolution.

Extremely Drug-Resistant Pseudomonas aeruginosa ST309 Harboring Tandem GES Enzymes: A Newly Emerging Threat in the United States

The paper identifies two U.S. clinical isolates of Pseudomonas aeruginosa ST309 resistant to carbapenems and beta-lactam/beta-lactamase inhibitor combinations, harboring tandem GES 19 and 26 enzymes, and reports successful treatment with ceftazidime/avibactam plus aztreonam.

Genomic and epidemiological evidence of a dominant Panton-Valentine leucocidin-positive Methicillin Resistant Staphylococcus aureus lineage in Sri Lanka with spread to the United Kingdom and Australia

The paper conducts genomic analysis of MRSA in Sri Lanka, identifying a dominant PVL-positive ST5-MRSA-IVc lineage that spreads internationally.

Speciation in a biodiversity hotspot: phylogenetic relationships, species delimitation, and divergence times of the Patagonian ground frogs of Eupsophus roseus group (Alsodidae)

This study investigates the phylogenetic relationships, species delimitation, and divergence times of the Eupsophus roseus group, identifying nine well-supported lineages and suggesting a new putative species.