A. Nayak

Discovery and Synthesis of GS-7682, a Novel Prodrug of a 4'-CN-4-Aza-7,9-Dideazaadenosine C-Nucleoside with Broad-Spectrum Potency Against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys.

This paper describes the discovery and synthesis of GS-7682, a prodrug with broad antiviral activity against RSV and other viruses, showing efficacy in RSV-infected monkeys.

Behavioral sequences across multiple animal species in the wild share common structural features

The paper analyzes behavioral sequences in three wild mammal species and finds consistent structural patterns across all species, individuals, and behavioral states.

Sorafenib induces muscle wasting by disrupting the activity of distinct chromatin regulators

This study shows Sorafenib causes muscle wasting by disrupting chromatin regulators, leading to transcriptional changes and impaired muscle function.

Sinefungin, a natural nucleoside analog of S-adenosyl methionine, impairs the pathogenicity of Candida albicans

This study shows that sinefungin, a nucleoside analog, reduces the pathogenicity of C. albicans by impairing hyphal growth, biofilm formation, and adhesion to human cells without harming human cells.

Targeting Nup358/RanBP2 by a viral protein disrupts stress granule formation

This paper identifies a viral protein that inhibits stress granule formation by targeting Nup358/RanBP2, revealing a mechanism by which viruses modulate cellular stress responses to promote infection.

Cardiac ventricular myosin and slow skeletal myosin exhibit dissimilar chemo-mechanical properties despite the same myosin heavy chain isoform.

This study compares the chemo-mechanical properties of cardiac ventricular and slow skeletal myosins with the same heavy chain isoform, finding distinct kinetic and mechanical behaviors.

Ca2+-inactivation of the mammalian ryanodine receptor type 1 in a lipidic environment revealed by cryo-EM

This study uses cryo-EM to reveal two conformations of RyR1 under Ca2+ conditions, showing how Ca2+ binding inactivates the channel through structural changes.

Single-molecule analysis reveals the role of regulatory light chains in fine-tuning skeletal myosin-II function

The paper investigates how regulatory light chains (RLCs) influence the functional diversity of myosin-II isoforms by swapping RLCs with different myosin heavy chains and measuring changes in actin filament sliding velocity.

Molecular mechanisms of Evening Complex activity in Arabidopsis

This paper identifies the molecular mechanisms of the Evening Complex (EC) in Arabidopsis, showing how ELF3 and ELF4 modulate LUX DNA binding and demonstrating structure-based engineering of a modified LUX allele that alters plant growth.