Clonal Evolution of Acute Myeloid Leukemia Revealed by High-Throughput Single-Cell Genomics
K. Morita, F. Wang, K. Jahn, J. Kuipers, Y. Yan, J. Matthews, L. Little, C. Gumbs, S. Chen, J. Zhang, X. Song, E. Thompson, K. Patel, C. Bueso-Ramos, C. D. DiNardo, , K. Takahashi
This study uses single-cell DNA sequencing to analyze clonal diversity in AML, revealing mutation co-occurrence, mutual exclusivity, and evolutionary patterns linked to treatment resistance and poor prognosis.
bioRxiv · Feb 7, 2020Cancer Biology