Author

L. Little

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

F. Wang· 3 shared G. Garcia-Manero· 3 shared J. Matthews· 3 shared J. Zhang· 3 shared K. Takahashi· 3 shared M. Konopleva· 3 shared A. Futreal· 2 shared C. Gumbs· 2 shared

Activity by Year

2020-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

F. Wang

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3 papers

Recent·Most cited

Leukemia stemness and co-occurring mutations drive resistance to IDH inhibitors in acute myeloid leukemia

F. Wang, K. Morita, C. DiNardo, K. Furudate, T. Tanaka, Y. Yan, K. Patel, K. MacBeth, B. Wu, G. Liu, M. Frattini, J. Matthews, L. Little, C. Gumbs, X. Song, , K. Takahashi

The paper identifies leukemia stemness and co-occurring mutations as drivers of resistance to IDH inhibitors in AML through genomic analyses of treated patients.

bioRxiv · Oct 27, 2020Cancer Biology

Single-cell Characterization of Acute Myeloid Leukemia and its Microenvironment Following PD-1 Blockade Based Therapy

H. A. Abbas, D. Hao, K. Tomczak, P. Baroodia, J. Im, P. K. Reville, Z. Alaniz, W. Wang, R. Wang, F. Wang, G. Al-Atrash, K. Takahashi, J. Ning, M. Ding, J. Matthews, , A. Futreal

This study analyzes single-cell RNA and TCR profiles from AML patients before and after PD-1 blockade therapy to identify factors influencing response and resistance.

bioRxiv · Sep 3, 2020Cancer Biology

Clonal Evolution of Acute Myeloid Leukemia Revealed by High-Throughput Single-Cell Genomics

K. Morita, F. Wang, K. Jahn, J. Kuipers, Y. Yan, J. Matthews, L. Little, C. Gumbs, S. Chen, J. Zhang, X. Song, E. Thompson, K. Patel, C. Bueso-Ramos, C. D. DiNardo, , K. Takahashi

This study uses single-cell DNA sequencing to analyze clonal diversity in AML, revealing mutation co-occurrence, mutual exclusivity, and evolutionary patterns linked to treatment resistance and poor prognosis.

bioRxiv · Feb 7, 2020Cancer Biology