K. Morita

Clinical factors associated with SFTS diagnosis and severity in cats

This study identifies clinical biomarkers and develops a scoring model to predict SFTSV infection in cats, while analyzing the relationship between viral strain and disease severity.

Drinking-Water 4,4'-Methylenedianiline Establishes a Longitudinally Tractable Mouse Model of Cholestatic Liver Injury

This paper develops a drinking-water model of cholestatic liver injury in mice using MDA, showing sustained ALT elevation and distinct histological and biochemical features compared to TAA-DW.

Network-based clustering unveils interconnected landscapes of genomic and clinical features across myeloid malignancies

The paper identifies novel subgroups in myeloid malignancies using a network-based clustering approach that integrates genomic and clinical features, improving prognostic accuracy.

A Tetravalent Dengue Virus-like Particle Vaccine Induces High levels of Neutralizing Antibodies and Inhibits Dengue Replication in Non-Human Primates

A tetravalent dengue VLP vaccine induces neutralizing antibodies and reduces viral replication in non-human primates without ADE.

Evolution of wheat blast resistance gene Rmg8 accompanied by differentiation of variants recognizing the powdery mildew fungus

The paper traces the evolutionary origin of wheat blast resistance gene Rmg8 and shows its ability to recognize both wheat blast and powdery mildew pathogens.

Breeding of a near-isogenic wheat line resistant to wheat blast at both seedling and heading stages through incorporation of Rmg8

This study introduces Rmg8 into a wheat cultivar to create near-isogenic lines resistant to wheat blast at both seedling and heading stages, showing broader resistance than existing genetic resources.

Rainbow trout in the inlet tributaries of Lake Chinishibetsu, Shiretoko Peninsula

This study examines the biology of rainbow trout in Lake Chinishibetsu's inlet tributaries, finding continuous reproduction and a dimorphic life history with river residents and lake migrants.

Structure and its transformation of elliptical nege-like virus Tanay virus

This study determines the cryo-EM structure of Tanay virus and reveals its dynamic shape changes under different conditions, suggesting structural roles in infection and assembly.

A statistical test for clonal exclusivity in tumour evolution

This paper introduces a statistical test, GeneAccord, to identify clonally exclusive gene pairs in tumours and applies it to AML data, finding 6 exclusive and 2 co-occurring pairs.

How does the magnitude of genetic variation affect eco-evolutionary dynamics in character displacement?

The paper examines how genetic variation magnitude influences evolutionary rescue through ecological and reproductive character displacement, finding that reproductive displacement relies more on additive genetic variance.

5-amino levulinic acid inhibits SARS-CoV-2 infection in vitro

This study shows that 5-ALA inhibits SARS-CoV-2 infection in vitro in both human and non-human cells with low cytotoxicity, suggesting it as a potential oral antiviral drug for COVID-19.

Leukemia stemness and co-occurring mutations drive resistance to IDH inhibitors in acute myeloid leukemia

The paper identifies leukemia stemness and co-occurring mutations as drivers of resistance to IDH inhibitors in AML through genomic analyses of treated patients.

Clonal Evolution of Acute Myeloid Leukemia Revealed by High-Throughput Single-Cell Genomics

This study uses single-cell DNA sequencing to analyze clonal diversity in AML, revealing mutation co-occurrence, mutual exclusivity, and evolutionary patterns linked to treatment resistance and poor prognosis.