K. Takahashi

Tumor-microvessel on-a-chip reveals sequential intravasation cascade of cancer cell clusters

This study develops a 3D in vitro system to visualize tumor intravasation of CTC clusters and identifies TGF-β and activin signaling as essential for this process.

Simple prerequisite of presequence for mitochondrial protein import in the unicellular red alga Cyanidioschyzon merolae

The paper investigates mitochondrial protein import in Cyanidioschyzon merolae by designing synthetic targeting peptides and showing that basic residues and specific amino acid composition are sufficient for import, with a simplified authentication mechanism involving TOM22.

Selective Translation Orchestrates Key Signaling Pathways in Primed Pluripotency

This study identifies EIF3D as a key regulator of primed pluripotency through selective translational control of signaling pathways and p53 regulators.

Activation of HIF2 leads to vascular remodeling and inflammation, coronary thrombosis and arterial dilation, recapitulating cardiac involvement of Kawasaki disease.

This study shows that activating HIF2 causes vascular remodeling, inflammation, and coronary issues similar to Kawasaki disease, using a new mouse model and human tissue analysis.

CtBP restricts DUX-dependent and -independent genetic program for the 2-cell-like state in murine embryonic stem cells

The paper shows that Ctbp1/2 disruption activates DUX-dependent and -independent pathways in mESCs, leading to 2-cell-like state features through PRAMEL7 upregulation.

Effect of mechanical stretching stimulation on maturation of human iPS cell-derived cardiomyocytes co-cultured with human gingival fibroblasts

This study shows that mechanical stretching improves the maturation and differentiation of human iPS cell-derived cardiomyocytes co-cultured with fibroblasts.

Development of a human heart-on-a-chip model using induced pluripotent stem cells, fibroblasts and endothelial cells

This paper develops a human heart-on-a-chip model using iPSC-derived cardiomyocytes, fibroblasts, and vascular endothelial cells, showing improved cardiac function and responses similar to in vivo hearts.

Network-based clustering unveils interconnected landscapes of genomic and clinical features across myeloid malignancies

The paper identifies novel subgroups in myeloid malignancies using a network-based clustering approach that integrates genomic and clinical features, improving prognostic accuracy.

BRG1/BRM inhibitor targets AML stem cells and exerts superior preclinical efficacy combined with BET or Menin inhibitor

This study shows that FHD-286, a BRG1/BRM inhibitor, reduces AML burden and improves survival when combined with Menin or BET inhibitors in xenograft models of AML with MLL1r or mtNPM1.

Transmission dynamics of symbiotic protist communities in the termite gut: association with host adult eclosion and dispersal

This study examines protist community dynamics during termite adult eclosion and dispersal, finding that changes in community composition enhance transmission efficiency.

SOD1 is a synthetic lethal target in PPM1D-mutant leukemia cells

This study identifies SOD1 as a synthetic lethal target in PPM1D-mutant leukemia cells through CRISPR/Cas9 screening, revealing a dysregulated redox landscape and potential therapeutic strategy.

Emergence of putative energy parasites within Clostridia revealed by genome analysis of a novel endosymbiotic clade

The paper identifies three endosymbiotic Clostridia in termite gut protists, revealing they are energy parasites with genome features suggesting obligate intracellular parasitism.

Swimming ability and flagellar motility of sperm packets of the volvocine green alga Pleodorina starrii

This study quantifies the motility differences between sperm packets and asexual colonies of Pleodorina starrii, revealing distinct flagellar waveform patterns and motility characteristics.

Diet-induced obesity dysregulates chromatin oxygen sensing regulating efferocytosis in macrophages

This study shows that diet-induced obesity disrupts chromatin oxygen sensing in macrophages, impairing hypoxia-induced glycolysis and efferocytosis.

Targeting MCL1-driven anti-apoptotic pathways to overcome hypomethylating agent resistance in RAS-mutated chronic myelomonocytic leukemia

This study identifies MCL1 as a survival factor in RAS-mutated CMML, explaining resistance to BCL2 inhibitors and suggesting new therapeutic targets.

Ring formation by Vibrio fusion protein composed of FliF and FliG, MS-ring and C-ring component of bacterial flagellar motor in membrane

This study constructs a FliF-FliG fusion protein that enables MS-ring formation in E. coli, revealing its role in flagellar motor assembly and force generation.

Clomipramine inhibits dynamin GTPase activity by L-α-phosphatidyl-L-serine stimulation

This study shows clomipramine inhibits GTPase activity of dynamin 2 and 3, similar to dynamin 1, suggesting it may block SARS-CoV-2 entry.

The bHLH transcription factor MpHYPNOS regulates gemma dormancy in the liverwort Marchantia polymorpha

This study identifies MpHYPNOS as a key regulator of gemma dormancy in liverworts, showing it represses cell cycle genes and induces ABA biosynthesis through an ABA-independent pathway.

Identification of domestic cat hepadnavirus from a cat blood sample in Japan

The study identifies a domestic cat hepadnavirus infection in a Japanese cat, showing genetic differences from global strains.

Morphological variation and phylogeny of Karenia selliformis (Gymnodiniales, Dinophyceae) in an intensive cold-water algal bloom in eastern Hokkaido, Japan in September-November 2021

The paper examines the morphology and phylogeny of Karenia selliformis and other co-occurred dinoflagellates in a harmful algal bloom in eastern Hokkaido, Japan, identifying morphological variation and genetic similarity to a bloom in Kamchatka, Russia.

A stress-reduced passaging technique improves the viability of human pluripotent cells

This paper introduces a stress-reduced passaging technique for human pluripotent stem cells that improves viability and downstream application efficiency without altering cell characteristics.

Aboveground biomass increments over 26 years (1993-2019) in an old-growth cool-temperate forest in northern Japan

This study tracks 26-year aboveground biomass changes in a Japanese old-growth forest, finding steady increases driven by compensating growth and climate factors.

A statistical test for clonal exclusivity in tumour evolution

This paper introduces a statistical test, GeneAccord, to identify clonally exclusive gene pairs in tumours and applies it to AML data, finding 6 exclusive and 2 co-occurring pairs.

A meta-analysis of Microarray Data is Effective for Identifying Gravity-Sensitive Genes

This study uses meta-analysis of DNA microarray data to identify gravity-sensitive genes, finding that SLCO2A1 expression decreases under microgravity.

Implications of cholesterol and sphingomyelin in STING phosphorylation by TBK1

The paper shows that cholesterol and sphingomyelin are required for TBK1-mediated phosphorylation of STING at the TGN, mirroring in vivo conditions.

Elevation-related climate trends dominate fungal co-occurrence patterns on Mt. Norikura, Japan

This study examines fungal co-occurrence networks along an elevation gradient on Mt. Norikura, finding that climate factors dominate network connectivity patterns, with significant declines between 700 m and 1500 m elevation.

The pluripotent stem cell-specific transcript ESRG is dispensable for human pluripotency

This study shows that ESRG, a HERV-H-driven lncRNA in human pluripotent stem cells, is not required for maintaining or reprogramming pluripotency.

Leukemia stemness and co-occurring mutations drive resistance to IDH inhibitors in acute myeloid leukemia

The paper identifies leukemia stemness and co-occurring mutations as drivers of resistance to IDH inhibitors in AML through genomic analyses of treated patients.

SARS-CoV-2 D614G Variant Exhibits Enhanced Replication ex vivo and Earlier Transmission in vivo

This study shows the SARS-CoV-2 D614G variant replicates more efficiently and transmits faster in hamsters than the wildtype virus.

Adaptive fitness in APC-mutant cells requires chromosome rearrangements

The paper shows that APC-mutant cells gain adaptive fitness through chromosome rearrangements that restore AURKA activity and counteract mitotic defects.