Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood-brain barrier microvessels
R. M. Linville, M. B. Sklar, G. N. Grifno, R. F. Nerenberg, J. Zhou, R. Ye, J. G. DeStefano, Z. Guo, R. Jha, J. J. Jamieson, N. Zhao, P. C. Searson
This study shows that a 3D microenvironment enhances BBB phenotype and function in iPSC-derived microvessels compared to 2D cultures.
bioRxiv · Aug 27, 2021Bioengineering