N. Zhao

CBP/P300 BRD Inhibition Reduces Neutrophil Accumulation and Activates Antitumor Immunity in TNBC

CBP/P300 BRD inhibition reduces neutrophil accumulation and enhances antitumor immunity in neutrophil-enriched TNBC, improving responses to standard therapies.

Disruption of Epithelium Integrity by Inflammation-Associated Fibroblasts through Prostaglandin Signaling

This study shows inflammation-associated fibroblasts disrupt colon epithelial barrier integrity and genome stability via PGE2-EP4 signaling, and EP4 inhibitors can reverse these effects.

Simulating Colloid Motion in Spinning Suspension: Internal Dynamics in Orbital Shaker

The paper presents a MATLAB simulation of colloid motion in orbital shakers to study particle dynamics in biomedical suspensions.

C5aR Expression in Kidney Tubules, Macrophages and Fibrosis

This study examines C5aR and C5L2 expression in kidney tissues and shows their role in inflammation and fibrosis through immune cell activation and extracellular matrix remodeling.

Hypoxia drives HIF2-dependent macrophage cell cycle entry and susceptibility to lentiviral transduction

This study shows hypoxia induces HIF2-dependent cell cycle entry in macrophages, leading to increased susceptibility to lentiviral transduction and is observed in tumor-associated macrophages.

Voluntary wheel running mitigates disease in an Orai1 gain-of-function mouse model of tubular aggregate myopathy

Voluntary wheel running improves muscle function and reduces tubular aggregates in a mouse model of tubular aggregate myopathy.

Targeting EIF4A triggers an interferon response to synergize with chemotherapy and suppress triple-negative breast cancer

Zotatifin targets EIF4A to suppress TNBC by inhibiting Sox4, inducing interferon response, and reprogramming the tumor immune microenvironment, synergizing with chemotherapy.

Population genomic analyses reveal extensive genomic regions within selective sweeps associated with adaptation and demographic history of a wheat fungal pathogen

This study uses population genomic analyses to identify genomic regions under selection and demographic history of the wheat rust pathogen Pst, revealing adaptation mechanisms and population size changes linked to wheat domestication and agriculture.

Mesenchymal stem cells ameliorate inflammation in an experimental model of Crohn's disease via the mesentery

This study shows that mesenchymal stem cells (MSCs) reduce inflammation in a mouse model of Crohn's disease by modulating T cells and macrophages in the mesentery, with long-term effects through macrophage reprogramming.

SUMOylation regulates Lem2 function in centromere clustering and silencing

The paper shows that SUMOylation of Lem2 in fission yeast affects centromere clustering and silencing by modulating its interactions with partner proteins.

Dynamics of Borrelia Burgdorferi Invasion and Intravasation in a Tissue Engineered Dermal Microvessel Model

This study uses a tissue-engineered human dermal microvessel model to investigate Borrelia burgdorferi invasion and intravasation, finding no adhesin-mediated interactions and showing Bb-induced endothelium activation.

Two Competing Guilds as a Core Microbiome Signature for Health Recovery

The paper identifies two competing bacterial guilds in the gut microbiome that correlate with host health conditions and can classify multiple diseases across diverse populations.

Nuclear Progestin Receptor Mediated Linkage of Blood Coagulation and Ovulation

This study shows that progestin receptors regulate coagulation factors during ovulation in zebrafish, linking blood clotting to the ovulation process.

Activation of transient receptor potential vanilloid 4 is involved in pressure overload-induced cardiac hypertrophy

This study shows TRPV4 activation contributes to pressure overload-induced cardiac hypertrophy through Ca2+/CaMKII-mediated NFκB-NLRP3 activation, suggesting TRPV4 as a therapeutic target.

Generation and diversification of recombinant monoclonal antibodies for studying mitosis

This study develops methods to generate low-cost, high-yield recombinant monoclonal antibodies and antibody fragments for studying mitosis and other applications.

Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood-brain barrier microvessels

This study shows that a 3D microenvironment enhances BBB phenotype and function in iPSC-derived microvessels compared to 2D cultures.

TMT-based proteomic analysis of the antibiotic effects of ShangKeHuangShui against Straphylococcus aureus.

This study uses TMT-based proteomics to analyze the antibacterial effects of YACTH against Staphylococcus aureus, identifying 490 differentially expressed proteins and their biological pathways.

CUB domain containing protein 1 (CDPC1) is a target for radioligand therapy in castration resistant prostate cancer

This paper evaluates CDCP1 as a target for radioligand therapy in mCRPC, showing its expression in most biopsies and demonstrating antitumor effects with 177Lu-4A06.

Visualizing looping of two endogenous genomic loci using synthetic zinc-finger proteins with anti-FLAG and anti-HA frankenbodies in living cells

The paper introduces a method to visualize two endogenous chromatin loci in living cells using synthetic zinc-finger proteins and frankenbodies, revealing their dynamic association and separation upon cohesin disruption.

A Drosophila Toolkit for Imaging of HA-tagged Proteins Unveiled a Block in Autophagy Flux in the Last Instar Larval Fat Body

Non-canonical Wnt/Ror2 signaling regulates cell-matrix crosstalk to prompt directional tumor cell invasion and dissemination in breast cancer

This study shows Ror2 regulates tumor cell-ECM interactions in breast cancer, promoting invasion through integrin and FAK pathways.

Extracellular vesicle molecular signatures characterize metastatic dynamicity in ovarian cancer

This study identifies a 7-gene extracellular vesicle signature associated with ovarian cancer metastasis but lacks a definitive signature due to limited sample size.

Establishment and Resilience of Transplanted Gut Microbiota in Aged Mice

This study investigates how age-matching between fecal microbiota transplantation (FMT) donors and aged recipients affects microbiota establishment and resilience, finding that mismatched age may reduce resilience against inflammation.

Topoisomerase 1 inhibition therapy protects against SARS-CoV-2-induced inflammation and death in animal models.

This study shows that Top1 inhibition with Topotecan reduces SARS-CoV-2-induced inflammation and mortality in animal models.

Impact of temporal pH fluctuations on the coexistence of nasal bacteria

The paper examines how temporal pH fluctuations affect nasal bacterial coexistence using experimental data and a mathematical model, finding that community composition is robust against pH changes.

Orthosteric-allosteric dual inhibitors of PfHT1 as selective anti-malarial agents

This paper develops dual orthosteric-allosteric inhibitors of PfHT1 that selectively target malaria parasites over human cells, showing potent activity against multidrug-resistant strains.

Exploiting KRAS-driven Ferroaddiction in Cancer Through Ferrous Iron-Activatable Drug Conjugates (FeADC)

This paper develops FeADCs, ferrous iron-activatable drug conjugates, to target KRAS-driven cancers with improved tumor selectivity and systemic tolerability.

Protein manipulation using single copies of short peptide tags in cultured cells and in Drosophila melanogaster

The paper demonstrates that single copies of short peptide tags can enable protein binding and manipulation in cultured cells and Drosophila, allowing degradation and relocalization of proteins of interest in vivo.

The impact of colonization history on the composition of ecological systems

This paper develops a theory linking colonization history to community composition, showing that community size, species connectivity, and growth rate variation influence the dominance of colonization history.

Reconstruction and dynamics of human intestinal microbiome observed in situ

This study samples ileocecal microbiome in situ using transendoscopic tubing and finds distinct metatranscriptomes compared to fecal samples, diurnal rhythms in bacterial activity, and metabolomic parallels to gut microbiome changes.