Author

P. C. Searson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1

Frequent Co-Authors

R. M. Linville· 3 shared J. G. DeStefano· 2 shared N. Zhao· 2 shared Z. Guo· 2 shared A. Ademola· 1 shared A. Komin· 1 shared A. Singh· 1 shared C. Chu· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersBioengineering

R. M. Linville

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Author profile →

3 papers

Recent·Most cited

Dynamics of Borrelia Burgdorferi Invasion and Intravasation in a Tissue Engineered Dermal Microvessel Model

Z. Guo, N. Zhao, T. D. Chung, A. Singh, I. Pandey, L. Wang, X. Gu, A. Ademola, R. M. Linville, U. Pal, J. S. Dumler, P. C. Searson

This study uses a tissue-engineered human dermal microvessel model to investigate Borrelia burgdorferi invasion and intravasation, finding no adhesin-mediated interactions and showing Bb-induced endothelium activation.

bioRxiv · Jul 10, 2022 · PreprintBioengineering

Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood-brain barrier microvessels

R. M. Linville, M. B. Sklar, G. N. Grifno, R. F. Nerenberg, J. Zhou, R. Ye, J. G. DeStefano, Z. Guo, R. Jha, J. J. Jamieson, N. Zhao, P. C. Searson

This study shows that a 3D microenvironment enhances BBB phenotype and function in iPSC-derived microvessels compared to 2D cultures.

bioRxiv · Aug 27, 2021Bioengineering

Reversible blood-brain barrier opening utilizing the membrane active peptide melittin in vitro and in vivo

R. M. Linville, A. Komin, X. Lan, J. G. DeStefano, C. Chu, G. Liu, P. Walczak, K. Hristova, P. C. Searson

This study demonstrates that melittin, a bee venom peptide, can reversibly open the blood-brain barrier in vitro and in vivo, enabling therapeutic delivery while maintaining neurological safety.

bioRxiv · Feb 9, 2021Bioengineering