SARS-CoV-2 inhibition in human airway epithelial cells using a mucoadhesive, amphiphilic chitosan that may serve as an anti-viral nasal spray
K. Pyrc, A. Milewska, E. B. Duran, P. Botwina, R. Lopes, A. Arenas-Pinto, M. Badr, R. Mellor, T. Kalber, D. Fernandez-Reyes, A. G. Schatzlein, I. F. Uchegbu
This paper demonstrates that GCPQ, a mucoadhesive chitosan derivative, reduces SARS-CoV-2 infectivity in cell cultures and shows promising nasal retention in mice, supporting its potential as a nasal spray for COVID-19 prevention.
bioRxiv · Dec 10, 2020 · PreprintPharmacology & Toxicology