K. Pyrc

An engineered A549 cell line expressing CD13 and TMPRSS2 is permissive to clinical isolate of human coronavirus 229E

The paper develops an A549 cell line expressing CD13 and TMPRSS2 that is permissive to a clinical isolate of HCoV-229E, enabling further study of the virus's infectiology.

Refolding of lid subdomain of SARS-CoV-2 nsp14 upon nsp10 interaction releases exonuclease activity.

The paper presents the crystal structure of SARS-CoV-2 nsp14 in apo-form and explains how nsp10 modulates its exonuclease activity through structural changes.

Despite the odds: formation of the SARS-CoV-2 methylation complex.

This study demonstrates that SARS-CoV-2 proteins nsp14, nsp10, and nsp16 form a heterotrimer complex, which modulates nsp14's exonuclease activity and protects viral RNA.

Efficacy of antiviral drugs against the omicron variant of SARS-CoV-2.

This study evaluates the efficacy of antivirals against SARS-CoV-2 variants, including Omicron, Delta, and the early 2020 isolate.

Acriflavine, a clinically aproved drug, inhibits SARS-CoV-2 and other betacoronaviruses

This study identifies acriflavine as a potent inhibitor of SARS-CoV-2 and other betacoronaviruses, effective in cellular models, in vivo, and ex vivo.

Zoonotic spillover of SARS-CoV-2: mink-adapted virus in humans

The paper reports the spillover of mink-adapted SARS-CoV-2 from farmed mink to humans, identifying specific mutations in the S gene.

Extracellular vimentin as a target against SARS- CoV-2 host cell invasion

The paper identifies extracellular vimentin as a potential target for preventing SARS-CoV-2 infection by showing it facilitates viral entry through interaction with the spike protein and ACE2.

SARS-CoV-2 inhibition in human airway epithelial cells using a mucoadhesive, amphiphilic chitosan that may serve as an anti-viral nasal spray

This paper demonstrates that GCPQ, a mucoadhesive chitosan derivative, reduces SARS-CoV-2 infectivity in cell cultures and shows promising nasal retention in mice, supporting its potential as a nasal spray for COVID-19 prevention.

Zika virus NS3 protease and its cellular substrates

This study investigates the cellular substrates of Zika virus NS3 protease but finds that biological validation is needed to confirm its protease activity's relevance.

The SARS-CoV-2 ORF10 is not essential in vitro or in vivo in humans.

The paper shows that SARS-CoV-2 ORF10 is not essential for viral replication or disease in humans, based on clinical and in vitro evidence.

HTCC as a highly effective polymeric inhibitor of SARS-CoV-2 and MERS-CoV

This paper evaluates HTCC as a potential inhibitor for SARS-CoV-2 and MERS-CoV, highlighting its antiviral activity against highly pathogenic coronaviruses.

Replication of SARS-CoV-2 in human respiratory epithelium

The paper presents a human airway epithelium model for studying SARS-CoV-2 replication and drug assessment, highlighting its potential as an alternative to animal models and Vero E6 cells.

Kallikrein 13: a new player in coronaviral infections.

This study identifies KLK13 as a protease required for HCoV-HKU1 infection and shows it cleaves the viral S protein, determining tissue specificity and potential interspecies transmission.