Haploinsufficient tumour suppressor PRP4K is negatively regulated during epithelial-to-mesenchymal transition
L. E. Clarke, A. Cook, S. Mathavarajah, A. Bera, J. Salsman, E. Habib, C. Van Iderstine, M. Bydoun, S. M. Lewis, G. Dellaire
This study shows PRP4K is a haploinsufficient tumor suppressor whose levels are reduced during EMT, promoting invasion without full EMT in mammary cells.
bioRxiv · Apr 19, 2020Cancer Biology