Evaluation of endogenous and therapeutic 25-hydroxycholesterols in murine models of pulmonary SARS-CoV-2 infection
M. B. Fessler, J. Madenspacher, P. J. Baker, K. L. Hilligan, E. Castro, J. Meacham, S.-H. Chen, R. F. Johnson, N. P. Martin, C. J. Tucker, D. Mahapatra, M. Cesta, K. D. Mayer-Barber
This study evaluates the antiviral and inflammatory effects of 25-hydroxycholesterol and its metabolite in murine SARS-CoV-2 models, finding no significant antiviral activity and potential pro-injury effects.
bioRxiv · Sep 12, 2022 · PreprintImmunology