K. D. Mayer-Barber

The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication

This study shows that pre-existing lung inflammation reduces SARS-CoV-2 replication by activating innate immune pathways, highlighting the role of the inflammatory microenvironment in controlling viral infection.

Pre-existing interferon gamma conditions the lung to mediate early control of SARS-CoV-2

This study shows that pre-existing IFN-gamma responses from bacterial infection reduce SARS-CoV-2 viral loads in the lungs and protect against disease in mice.

A TNF-IL-1 circuit controls Yersinia within intestinal granulomas

This study identifies a monocyte-intrinsic TNF-IL-1 circuit that controls Yersinia infection within intestinal granulomas by signaling to non-hematopoietic cells.

Helminth exposure protects against murine SARS-CoV-2 infection through macrophage dependent T cell activation

This study shows that prior helminth infection reduces SARS-CoV-2 viral loads in mice by enhancing CD8+ T cell responses through macrophage-dependent mechanisms.

Blood and site of disease inflammatory profiles differ in HIV-1-infected pericardial tuberculosis patients

This study compares inflammatory profiles in blood and pericardial fluid of HIV-1-infected individuals with latent TB, PTB, and PCTB, finding site-specific elevation of analytes and HLA-DR as a better TB diagnostic marker.

Evaluation of endogenous and therapeutic 25-hydroxycholesterols in murine models of pulmonary SARS-CoV-2 infection

This study evaluates the antiviral and inflammatory effects of 25-hydroxycholesterol and its metabolite in murine SARS-CoV-2 models, finding no significant antiviral activity and potential pro-injury effects.

Profile of Mycobacterium tuberculosis-specific CD4 T cells at the site of disease and blood in pericardial tuberculosis

This study compares Mtb-specific CD4 T cell profiles in pericardial fluid and blood from PCTB patients, finding distinct phenotypes in PCF with no difference in cytokine production.

Rapid GPR183-mediated recruitment of eosinophils to the lung after Mycobacterium tuberculosis infection

This study shows that eosinophils migrate to the lungs early after Mycobacterium tuberculosis infection in mice and macaques, mediated by GPR183 and Ch25h, independent of CCR3.

Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challenge

This study shows that intravenous BCG vaccination protects mice from lethal SARS-CoV-2 infection by altering pulmonary myeloid cell function and reducing immunopathology.

Eosinophils are an integral component of the pulmonary granulocyte response in Tuberculosis and promote host resistance in mice

This study shows eosinophils are recruited to tuberculosis-infected lung tissue in mice and contribute to host resistance against Mtb infection.

IL-1R1 dependent signals improve clearance of cytosolic virulent mycobacteria in vivo

The paper shows that IL-1R1-dependent signals enhance clearance of cytosolic mycobacteria in vivo, particularly when host immunity is compromised.

PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques

This study shows that PD-1 blockade worsens Mycobacterium tuberculosis infection in rhesus macaques by increasing bacterial loads and altering immune responses.