Author

M. B. Fessler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 5 Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Research Focus:differential expression· 1

Frequent Co-Authors

A. Solis· 2 shared C. J. Tucker· 2 shared J. J. Aloor· 2 shared R. M. Tighe· 2 shared S. Garantziotis· 2 shared S. Hussain· 2 shared X. Meng· 2 shared Y. Sakamachi· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersImmunology

A. Solis

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Author profile →

6 papers

Recent·Most cited

Toll-Like-Receptor 5 protects against pulmonary fibrosis by reducing lung dysbiosis

A. Gleiberman, R. Invernizzi, P. L. Molyneaux, B. G. Wu, Y. Lipinski, M. Kugler, L. N. Segal, Y. Sakamachi, E. Wiley, A. Solis, C. G. Johnson, X. Meng, J. Malphurs, B. Papas, S. Mehta, , N. Kaminski

TLR5 deficiency is linked to pulmonary fibrosis due to its role in preventing microbial dysbiosis following lung injury.

bioRxiv · Apr 30, 2024 · PreprintImmunology

Flotillin-2 dampens T cell antigen-sensitivity and functionality

S. Moon, F. Zhao, M. Uddin, C. J. Tucker, P. W. F. Karmaus, M. B. Fessler

This study shows that Flotillin-2 reduces T cell sensitivity to weak antigen stimulation by regulating TCR clustering and signaling.

bioRxiv · Apr 26, 2024Immunology

Tissue-resident alveolar macrophages reduce O3-induced inflammation via MerTK mediated efferocytosis

M. A. Guttenberg, A. T. Vose, A. Birukova, K. Lewars, R. I. Cumming, M. C. Albright, J. I. Mark, C. J. Salazar, S. Swaminathan, Z. Yu, Y. V. Sokolenko, E. Bunyan, M. J. Yaeger, M. B. Fessler, L. G. Que, , R. M. Tighe

This study shows tissue-resident alveolar macrophages reduce O3-induced inflammation by clearing apoptotic cells via MerTK-mediated efferocytosis in mice and humans.

bioRxiv · Nov 6, 2023 · PreprintImmunology

Evaluation of endogenous and therapeutic 25-hydroxycholesterols in murine models of pulmonary SARS-CoV-2 infection

M. B. Fessler, J. Madenspacher, P. J. Baker, K. L. Hilligan, E. Castro, J. Meacham, S.-H. Chen, R. F. Johnson, N. P. Martin, C. J. Tucker, D. Mahapatra, M. Cesta, K. D. Mayer-Barber

This study evaluates the antiviral and inflammatory effects of 25-hydroxycholesterol and its metabolite in murine SARS-CoV-2 models, finding no significant antiviral activity and potential pro-injury effects.

bioRxiv · Sep 12, 2022 · PreprintImmunology

TLR5 participates in the TLR4 receptor complex and biases towards MyD88-dependent signaling in environmental lung injury

S. Hussain, C. C. Johnson, J. Sciurba, X. Meng, V. P. Stober, C. Liu, J. Cypher-Daly, K. Bulek, W. Qian, A. Solis, Y. Sakamachi, C. Trempus, J. J. Aloor, K. Gowdy, W. M. Foster, , S. Garantziotis

This study shows TLR5 associates with TLR4 and biases its signaling toward MyD88 in lung injury responses to LPS, hyaluronan, and O3.

bioRxiv · Oct 3, 2019Immunology

Crosslinking Proteomics Indicates Effects of Simvastatin on the TLR2 interactome and Reveals ACTR1A as a Novel Regulator of the TLR2 Signal Cascade

A. H. M. Kamal, J. J. Aloor, M. B. Fessler, S. Chowdhury

This study uses crosslinking proteomics to show that simvastatin alters the TLR2 interactome and identifies ACTR1A as a new regulator of TLR2 signaling.

bioRxiv · Jan 26, 2019Immunology