Evolutionary BiologybioRxiv
Constraints on the evolution of toxin-resistant Na,K-ATPases have limited dependence on sequence divergence
S. Mohammadi, S. Herrera-Alvarez, L. Yang…·P. Andolfatto
The paper investigates how intramolecular epistasis affects the evolution of CTS-resistant Na,K-ATPases, finding that resistance substitutions have pleiotropic effects independent of sequence divergence.
DOI 10.1371/journal.pgen.1010323