Author

A. Harpak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 4 Genomics· 1

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Approach:statistical model· 4 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Assay:whole-genome sequencing· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Organism:E. coli· 1

Frequent Co-Authors

A. Akbari· 1 shared A. J. Crawford· 1 shared A. M. Joergensen· 1 shared D. A. Petrov· 1 shared D. Reich· 1 shared E. A. Boyle· 1 shared F. Racimo· 1 shared G. Coop· 1 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperGenomics

A. Akbari

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Author profile →

5 papers

Recent·Most cited

1,000 ancient genomes uncover 10,000 years of natural selection in Europe

M. K. Le, O. S. Smith, A. Akbari, A. Harpak, D. Reich, V. M. Narasimhan

This study analyzes 1,000 ancient genomes to identify genetic changes linked to natural selection in Europe over 10,000 years, revealing adaptation to cultural shifts and disease.

bioRxiv · Aug 24, 2022 · PreprintGenomics

The mutability of demographic noise in microbial range expansions

Q. Yu, M. Gralka, M.-C. Duvernoy, M. Sousa, A. Harpak, O. Hallatschek

This study measures how single gene deletions in E. coli affect demographic noise during range expansions, finding that mutations can reduce noise and enhance beneficial mutation establishment.

bioRxiv · Oct 27, 2020Evolutionary Biology

Concerted evolution reveals co-adapted amino acid substitutions in Na+K+-ATPase of frogs that prey on toxic toads

S. Mohammadi, L. Yang, A. Harpak, S. Herrera-Alvarez, M. d. P. Rodriguez-Ordonez, J. Peng, K. Zhang, J. F. Storz, S. Dobler, A. J. Crawford, P. Andolfatto

The paper shows that selection maintains adaptive division-of-labor between tandem duplicates of ATP1A1 in frogs, countering gene conversion to confer toxin resistance.

bioRxiv · Aug 4, 2020Evolutionary Biology

Genetic Adaptation in New York City Rats

A. Harpak, N. Garud, N. A. Rosenberg, D. A. Petrov, M. Combs, P. S. Pennings, J. Munshi-South

The paper investigates genetic adaptation in New York City rats by analyzing whole-genome sequences to identify signatures of selection related to urban living.

bioRxiv · Feb 7, 2020Evolutionary Biology

Reduced signal for polygenic adaptation of height in UK Biobank

J. J. Berg, A. Harpak, N. Sinnott-Armstrong, A. M. Joergensen, H. Mostafavi, Y. Field, E. A. Boyle, X. Zhang, F. Racimo, J. K. Pritchard, G. Coop

The paper analyzes polygenic height scores from UK Biobank and finds reduced signals of selection compared to previous studies, suggesting potential issues with population stratification correction.

bioRxiv · Dec 10, 2018Evolutionary Biology