Author

J. van Unen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Approach:experimental assay· 3 Assay:fluorescence / live-cell microscopy· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Assay:imaging· 1 Approach:mechanistic / dynamical model· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

J. Goedhart· 2 shared O. Pertz· 2 shared T. W. J. Gadella· 2 shared A. Honigmann· 1 shared A. Torres-Sanchez· 1 shared C. Martin-Lemaitre· 1 shared C. R. Zuconelli· 1 shared D. Botman· 1 shared

Activity by Year

2016-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCell Biology

J. Goedhart

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

GTPase activating protein DLC1 spatio-temporally regulates Rho signaling

L. Hinderling, M. Heydasch, G. Rochat, L. Dubied, J. van Unen, M. Dobrzynski, O. Pertz

This study shows DLC1 regulates Rho activity levels globally and amplifies local Rho activity at focal adhesions under mechanical stress.

bioRxiv · Jun 19, 2023Cell Biology

Polarity-driven three-dimensional spontaneous rotation of a cell doublet

L. Lu, T. Guyomar, Q. Vagne, R. Berthoz, A. Torres-Sanchez, M. Lieb, C. Martin-Lemaitre, J. van Unen, A. Honigmann, O. Pertz, G. Salbreux, D. Riveline

This study investigates how myosin polarity drives spontaneous 3D rotation in cell doublets embedded in an extracellular matrix.

bioRxiv · Dec 21, 2022Biophysics

A FRET based biosensor for measuring Gα13 activation in single cells

M. Mastop, N. R. Reinhard, C. R. Zuconelli, F. Terwey, T. W. J. Gadella, J. van Unen, M. J. W. Adjobo-Hermans, J. Goedhart

The paper develops a FRET-based biosensor to measure Gα13 activation in single cells and demonstrates its use in detecting receptor-induced responses.

bioRxiv · Nov 16, 2017Cell Biology

Palmitoylation of the oncogenic RhoGEF TGAT is dispensable for membrane localization and consequent activation of RhoA

J. van Unen, D. Botman, T. Yin, Y. I. Wu, M. A. Hink, T. W. J. Gadella, M. Postma, J. Goedhart

This study shows that membrane association of TGAT is critical for its activity, but palmitoylation is not required for membrane localization or RhoA activation.

bioRxiv · Aug 9, 2016Cell Biology