Mast cell-mediated inflammation relies on insulin-regulated aminopeptidase controlling cytokine export from the Golgi
M. Weimershaus, C. Carvalho, E. Enee, R. Rignault, M. Dussiot, P. van Endert, T. T. Maciel, O. Hermine
This study identifies IRAP as a regulator of cytokine export from the Golgi in mast cells, showing its role in TNF- and IL-6 secretion and its therapeutic potential in inflammation.
bioRxiv · Jan 21, 2022Immunology