Cell BiologybioRxivPreprint
Structural basis for mTORC1-dependent regulation of the lysosomal and autophagic transcription factor TFEB
Z. Cui, G. Napolitano, M. E. G. de Araujo…·J. H. Hurley
This paper determines the structural basis of mTORC1-dependent phosphorylation of TFEB using cryo-EM, revealing how TFEB is presented to mTORC1 for phosphorylation through a unique RagC GDP-dependent mechanism.
DOI 10.1101/2022.09.12.507619