Author

J. Monfregola

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 2 Assay:cryo-EM· 1 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

A. Ballabio· 2 shared A. Esposito· 2 shared G. Napolitano· 2 shared A. Eva· 1 shared B. Hay Mele· 1 shared C. Di Malta· 1 shared D. Antonini· 1 shared D. Intartaglia· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCell Biology

A. Ballabio

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Author profile →

3 papers

Recent·Most cited

Ezrin defines TSC complex activation at endosomal compartments through EGFR-AKT signaling.

G. Giamundo, D. Intartaglia, E. Del Prete, E. Polishchuk, F. Andreone, M. Ognibene, S. Buonocore, B. Hay Mele, F. G. Salierno, J. Monfregola, D. Antonini, P. Grumati, A. Eva, R. De Cegli, I. Conte

The paper identifies Ezrin's role in regulating TSC complex activation at endosomes via EGFR-AKT signaling, showing its impact on mTORC1 and retinal function.

bioRxiv · May 3, 2024Cell Biology

Structural basis for mTORC1-dependent regulation of the lysosomal and autophagic transcription factor TFEB

Z. Cui, G. Napolitano, M. E. G. de Araujo, A. Esposito, J. Monfregola, L. Huber, A. Ballabio, J. H. Hurley

This paper determines the structural basis of mTORC1-dependent phosphorylation of TFEB using cryo-EM, revealing how TFEB is presented to mTORC1 for phosphorylation through a unique RagC GDP-dependent mechanism.

bioRxiv · Sep 12, 2022 · PreprintCell Biology

mTOR-dependent phosphorylation controls TFEB nuclear export

G. Napolitano, A. Esposito, H. Choi, V. Benedetti, M. Matarese, C. Di Malta, J. Monfregola, D. L. Medina, J. Lippincott-Schwartz, A. Ballabio

This study identifies mTOR-dependent phosphorylation of TFEB as a mechanism controlling its nuclear export and activity during nutrient re-feeding.

bioRxiv · Jun 5, 2018Cell Biology