Sex differences in bile acid homeostasis and excretion underlie the disparity in liver cancer incidence between males and females.
M. E. Patton, S. Kelekar, L. J. Taylor, A. E. Dean, Q. Zuo, R. N. Thakare, S. H. Lee, E. Gentry, M. Panitchpakdi, P. Dorrestein, Y. Alnouti, Z. Madak-Erdogan, J.-S. Lee, M. J. Finegold, S. Anakk
This study identifies sex-specific bile acid metabolism differences that protect female livers from liver cancer and suggests targeting bile acid excretion as a therapeutic strategy.
bioRxiv · Jun 25, 2020Cancer Biology