Author

S. Kelekar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:metabolomics· 3 Research Focus:metabolism & bioenergetics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

D. Do· 3 shared F. Cai· 3 shared H. S. Vu· 3 shared L. Cai· 3 shared R. J. DeBerardinis· 3 shared Z. Wu· 3 shared B. Brooks· 2 shared C. R. Malloy· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiochemistry

D. Do

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Electron transport inhibition increases cellular dependence on purine transport and salvage

Z. Wu, D. Bezwada, R. C. Harris, C. Pan, P. T. Nguyen, B. Faubert, L. Cai, F. Cai, H. S. Vu, H. Chen, M. Martin-Sandoval, D. Do, W. Gu, Y. Zhang, B. Ko, , R. J. DeBerardinis

This study shows that ETC inhibition in cancer cells increases reliance on purine salvage and transport, revealing a metabolic vulnerability in tumors with low oxidative metabolism.

bioRxiv · May 11, 2023Biochemistry

Mitochondrial metabolism in primary and metastatic human kidney cancers

D. Bezwada, R. J. DeBerardinis, N. P. Lesner, B. Brooks, H. S. Vu, Z. Wu, L. Cai, S. Kasitinon, S. Kelekar, F. Cai, A. B. Aurora, M. Patrick, A. Leach, R. Ghandour, Y. Zhang, , V. Margulis

This study investigates mitochondrial metabolism in kidney cancers, finding that primary tumors have suppressed mitochondrial function while metastases show enhanced TCA cycle labeling.

bioRxiv · Feb 6, 2023Cancer Biology

Comprehensive isotopomer analysis of glutamate and aspartate in small tissue samples

F. Cai, D. J. Bezwada, L. Cai, R. Mahar, Z. Wu, P. Pachnis, C. Yang, S. Kelekar, W. Gu, H. S. Vu, T. P. Mathews, L. G. Zacharias, M. Martin-Sandoval, D. Do, K. C. Oaxaca, , R. J. DeBerardinis

This paper develops an MS method to analyze all 16 aspartate and 32 glutamate isotopomers with high sensitivity, enabling pathway discrimination and metabolic heterogeneity studies in human tumors.

bioRxiv · Jul 31, 2022Biochemistry

Sex differences in bile acid homeostasis and excretion underlie the disparity in liver cancer incidence between males and females.

M. E. Patton, S. Kelekar, L. J. Taylor, A. E. Dean, Q. Zuo, R. N. Thakare, S. H. Lee, E. Gentry, M. Panitchpakdi, P. Dorrestein, Y. Alnouti, Z. Madak-Erdogan, J.-S. Lee, M. J. Finegold, S. Anakk

This study identifies sex-specific bile acid metabolism differences that protect female livers from liver cancer and suggests targeting bile acid excretion as a therapeutic strategy.

bioRxiv · Jun 25, 2020Cancer Biology