Author

J.-S. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Immunology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 6 Research Focus:cell signaling & trafficking· 5 Approach:experimental assay· 5 Assay:bulk RNA-seq· 4 Research Focus:cell type annotation· 3 Approach:genetic perturbation / CRISPR· 3 Approach:statistical model· 3 Research Focus:differential expression· 2

Frequent Co-Authors

D.-M. Yu· 3 shared H. Lee· 3 shared S.-H. Koo· 3 shared Y.-G. Ko· 3 shared H.-S. Lee· 2 shared J.-S. Kim· 2 shared M.-S. Bahn· 2 shared S. Lee· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersCell Biology

D.-M. Yu

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Fluorescent tagging of endogenous IRS2 with an auxin-dependent degron to assess dynamic intracellular localization and function

M. Jo, J.-S. Lee, M. W. Lero, J. S. Morgan, L. M. Shaw

This study uses CRISPR/Cas9 to fluorescently tag endogenous IRS2 with an auxin-dependent degron, revealing its dynamic nuclear-cytoplasmic shuttling and role in cancer stem cell function.

bioRxiv · Dec 6, 2023Cell Biology

MARCH5-dependent NLRP3 ubiquitination is an essential step for NEK7 docking on the mitochondria

Y.-J. Park, N. Dodantenna, T.-H. Kim, H.-S. Lee, Y.-S. Yoo, E.-S. Lee, J.-H. Lee, M.-H. Kwon, H. C. Kang, J.-S. Lee, H. Cho

This study identifies MARCH5-dependent NLRP3 ubiquitination as essential for NEK7 mitochondrial docking during inflammasome assembly.

bioRxiv · Jan 12, 2023 · PreprintImmunology

Central role of Prominin-1 in lipid rafts during liver regeneration

M.-S. Bahn, D.-M. Yu, M. Lee, S.-J. Jo, J.-W. Lee, H. Lee, A. Kim, J.-H. Hong, J.-S. Kim, S.-H. Koo, J.-S. Lee, Y.-G. Ko

This study shows PROM1 is crucial in lipid rafts for liver regeneration by recruiting GP130 and activating the IL6-GP130-STAT3 pathway.

bioRxiv · Jan 20, 2022Cell Biology

Inhibition of CDK4/6 Overcomes Primary Resistance to PD-1 Blockade in Malignant Mesothelioma

H.-J. Jang, C. Y. Truong, E. M. Lo, H. M. Holmes, D. Ramos, M. Ramineni, J.-S. Lee, D. Y. Wang, M. Pietropaolo, R. T. Ripley, B. Burt, H.-S. Lee

This study identifies CDK4/6 as a therapeutic target to overcome primary resistance to PD-1 blockade in malignant mesothelioma by analyzing genomic and immunogenomic data.

bioRxiv · Mar 4, 2021Immunology

Host transcriptional response to TB preventive therapy differentiates two sub-groups of IGRA-positive individuals

C. Broderick, J. M. Cliff, J.-S. Lee, M. Kaforou, D. A. Moore

The paper analyzes transcriptional responses to tuberculosis preventive therapy in IGRA-positive individuals, identifying two subgroups with distinct gene expression patterns linked to Mtb viability.

bioRxiv · Jul 20, 2020Immunology

Sex differences in bile acid homeostasis and excretion underlie the disparity in liver cancer incidence between males and females.

M. E. Patton, S. Kelekar, L. J. Taylor, A. E. Dean, Q. Zuo, R. N. Thakare, S. H. Lee, E. Gentry, M. Panitchpakdi, P. Dorrestein, Y. Alnouti, Z. Madak-Erdogan, J.-S. Lee, M. J. Finegold, S. Anakk

This study identifies sex-specific bile acid metabolism differences that protect female livers from liver cancer and suggests targeting bile acid excretion as a therapeutic strategy.

bioRxiv · Jun 25, 2020Cancer Biology

Hepatocytic Prominin-1 protects against liver fibrosis by stabilizing the SMAD7 protein

H. Lee, D.-M. Yu, M. J. Um, S. Y. Yoon, K.-T. Kim, Y. J. Kwon, S. Lee, M.-S. Bahn, S.-H. Koo, K. H. Jung, J.-S. Lee, Y.-G. Ko

This study shows that hepatocytic Prominin-1 prevents liver fibrosis by stabilizing SMAD7, thereby inhibiting TGFβ signaling.

bioRxiv · Nov 19, 2019 · PreprintCell Biology

Prominin-1-Radixin Axis controls hepatic gluconeogenesis by regulating PKA activity

H. Lee, D.-M. Yu, J.-S. Park, H. Lee, J.-S. Kim, S.-H. Koo, J.-S. Lee, S. Lee, Y.-G. Ko

The paper shows that Prom1 regulates hepatic gluconeogenesis by modulating PKA activity through its interaction with radixin.

bioRxiv · Sep 27, 2019Cell Biology