PDH Mediated Mitochondrial Respiration Controls the Speed of Muscle Stem Cell Activation in Muscle Repair and Aging
M. H. Raval, P.-C. Cheng, N. Guardino, S. Ahsan, H. Zhou, R. L. Tiwari, L. Wang, A. Chareunsouk, M. Ederer, A. B. Hwang, M. Ellenberger, R. Pepin, D. Pormislow, K. Shen, A. S. Brack, J. T. Rodgers
This study shows that mitochondrial respiration via PDH controls the speed of muscle stem cell activation, which declines with age, and that restoring PDH activity can improve muscle regeneration in aged mice.
bioRxiv · Feb 14, 2020 · PreprintCell Biology