M. Escude

Second generation of LNP based mRNA vaccine leads to a T-cell-inflamed tumor microenvironment favorable for improving PD-1/PD-L1 blocking therapy and long-term immunity in a cold tumor model

This study shows that second-generation LNPs (Lipidots(R)) enhance antitumor immunity by remodeling the tumor microenvironment and synergizing with PD-1/PD-L1 blockade to improve therapeutic outcomes in cold tumors.

Tuning the immunostimulation properties of cationic lipid nanocarriers for nucleic acid delivery

This study investigates how cationic lipid nanocarriers affect macrophages and dendritic cells, showing that adjusting nucleic acid load can mitigate adverse immune responses.