T. Decaens

Second generation of LNP based mRNA vaccine leads to a T-cell-inflamed tumor microenvironment favorable for improving PD-1/PD-L1 blocking therapy and long-term immunity in a cold tumor model

This study shows that second-generation LNPs (Lipidots(R)) enhance antitumor immunity by remodeling the tumor microenvironment and synergizing with PD-1/PD-L1 blockade to improve therapeutic outcomes in cold tumors.

Environmental drivers of earthworm communities along an altitudinal gradient in the French Alps

The paper examines earthworm communities along an altitudinal gradient in the French Alps, finding that treeline ecotones, rather than altitude alone, drive community diversity and abundance.

Targeting PPT1 with ezurpimtrostat sensitives liver tumor to immunotherapy by switching cold into hot microenvironments

This paper shows that inhibiting PPT1 with ezurpimtrostat enhances anti-PD-1 immunotherapy in liver cancer by converting cold to hot tumors.

Hepatocellular carcinoma hosts immature neurons and cholinergic tumors that correlate with adverse molecular features and outcomes

This study identifies neural features in hepatocellular carcinoma, showing cholinergic tumors correlate with adverse molecular traits and worse outcomes.

Phylogenomics Illuminates the Evolutionary History of Wild Silkmoths in Space and Time (Lepidoptera: Saturniidae)

This study reconstructs the evolutionary history of wild silkmoths using phylogenomic data, revealing a Neotropical origin and two Old World colonization events, along with taxonomic rearrangements.

A \"Dirty\" Footprint: Anthropogenic Soils Promote Biodiversity in Amazonian Rainforests

The paper examines soil macroinvertebrate communities in Amazonian Dark Earths (ADEs) and finds higher biodiversity and biological activity compared to adjacent soils, highlighting the impact of human activities on Amazonian ecosystems.

GNS561, a new autophagy inhibitor active against cancer stem cells in hepatocellular carcinoma and hepatic metastasis from colorectal cancer

This study shows that GNS561, an autophagy inhibitor, effectively targets both cancer stem cells and bulk tumor cells in hepatocellular carcinoma and colorectal cancer metastasis.

Hypoxia Drives Dihydropyrimidine Dehydrogenase Expression in Macrophages and Confers Chemoresistance in Colorectal Cancer

This study identifies hypoxia-driven DPD expression in tumor-associated macrophages as a mechanism of 5-FU chemoresistance in colorectal cancer, with species-specific differences observed between human and mouse models.

GNS561, a clinical-stage PPT1 inhibitor, is efficient against hepatocellular carcinoma via modulation of lysosomal functions

This paper evaluates GNS561, a PPT1 inhibitor, showing its efficacy against HCC by modulating lysosomal functions and inducing cell death in vitro and in vivo.