Succinylation Links Metabolic Reductions to Amyloid and Tau Pathology
Yun Yang, Vı́ctor Tapias, Diana M. Acosta, Hui Xu, Huan‐Lian Chen, Ruchika P. Bhawal, Elizabeth Anderson, Elena Ivanova, Hening Lin, Botir T. Sagdullaev, William L. Klein, Kirsten L. Viola, Sam Gandy, Vahram H. Haroutunian, M. Flint Beal, , Gary E. Gibson
This study identifies lysine succinylation as a post-translational modification linked to amyloid and tau pathology in Alzheimer's disease through human brain and mouse model analyses.
bioRxiv · Sep 16, 2019 · PreprintNeuroscience