Hening Lin

HDAC5 tunes effector competence in differentiated human CD8+ T cells through an ACTL6A-IRF4 axis

This study identifies HDAC5 as a regulator of effector competence in human CD8+ T cells, showing it modulates cytokine responses and TCR activation through an ACTL6A-IRF4 axis.

FAK Dependent Focal Adhesion Remodeling Drives Arsenical Vesicant Induced Skin Injury

This study shows that FAK activation drives PAO-induced skin injury by disrupting focal adhesions, and inhibiting FAK protects against vesicant-induced damage.

Development of GS-441524 Derivatives as Potent SARS-CoV-2 Mac1 Inhibitors via a Direct-to-Biology Approach

The paper develops potent SARS-CoV-2 Mac1 inhibitors through a direct-to-biology approach, improving the potency of GS-441524 to KP-S54 with IC50 values of 44 nM and 91 nM against SARS-CoV-2 and MERS-CoV Mac1, respectively.

SIRT2 Mediates Integrated Stress Response by Deacetylating and Stabilizing 4EBP1 to Suppress Translation

This study identifies SIRT2 as a regulator of translation by deacetylating and stabilizing 4EBP1, which suppresses protein synthesis under amino acid limitation.

Coenzyme A is a redox sensing cofactor for malic enzyme 2 regulating oxidative stress and mitochondrial metabolism

This study identifies CoA as a redox-sensing cofactor for ME2, showing it regulates oxidative stress and mitochondrial metabolism through conformational changes and NADPH production.

A High-throughput Fluorescence Polarization Assay for Screening Sirtuin Inhibitors

The paper develops a high-throughput fluorescence polarization assay to screen SIRT1-3 inhibitors, showing improved efficiency and performance compared to existing methods.

SIRT5 acts in the tumor microenvironment via endothelial cell metabolism to support breast cancer growth

This study identifies SIRT5 as a regulator of endothelial cell metabolism in the tumor microenvironment, showing its role in supporting breast cancer growth through vascular function.

DHHC7 palmitoylates KRAS4A and promotes mutant KRAS-driven pancreatic cancers

This study identifies DHHC7 as a palmitoyl transferase that modifies KRAS4A, enhancing its membrane localization and activation, and shows that targeting DHHC7 inhibits pancreatic tumor growth.

Cryo-EM structure revealed a novel F-actin binding motif in a Legionella pneumophila lysine fatty-acyltransferase

The paper identifies a novel F-actin binding motif in Lfat1, a Legionella effector, using cryo-EM and shows its lysine fatty-acyltransferase activity.

Sirtuin 2 controls global protein synthesis by regulating Rheb-GTPase

This study identifies SIRT2 as a regulator of global protein synthesis by modulating Rheb-GTPase activity, showing its potential as a therapeutic target for diseases with increased protein synthesis.

Succinylation Links Metabolic Reductions to Amyloid and Tau Pathology

This study identifies lysine succinylation as a post-translational modification linked to amyloid and tau pathology in Alzheimer's disease through human brain and mouse model analyses.