Author

William L. Klein

Northwestern UniversityORCID 0000-0002-3047-9978Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:imaging· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

Kirsten L. ViolaiD· 3 shared Abhay Gupta· 1 shared Adrian M. BebenekiD· 1 shared Adriano SebollelaiD· 1 shared Alberto Luis EpsteiniD· 1 shared Amanda Santos de SouzaiD· 1 shared Anderson S. Peck· 1 shared Andre L.B. Bitencourt· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersNeuroscience

Kirsten L. ViolaORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

AAV-mediated neuronal expression of a scFv antibody selective for Aβ oligomers protects synapses and rescues memory in Alzheimer models

María Clara Sellés, Juliana T.S. Fortuna, Magalí Cecilia Cercato, Luís E. Santos, Luciana Domett, Andre L.B. Bitencourt, Mariane Favero Carraro, Amanda Santos de Souza, Helena Janíčková, Caroline Vieira Azevedo, Henrique Correia Campos, Jorge Marcondes de Souza, Soniza Vieira Alves‐Leon, Vânia F. Prado, Marco A. M. Prado, , Sergio Teixeira Ferreira

This study shows that AAV-delivered scFv antibodies targeting Aβ oligomers protect synapses and rescue memory in Alzheimer's disease models.

Molecular Therapy · Nov 11, 2022Peer-reviewedNeuroscience

The therapeutic and diagnostic potential of amyloid β oligomers (AβOs) selective antibodies to treat Alzheimer's disease

Kirsten L. Viola, Maira Assunção Bicca, Adrian M. Bebenek, Daniel L. Kranz, Vikas Nandwana, Emily Alexandria Waters, Chad R. Haney, Maxwell Y Lee, Abhay Gupta, Zachary Brahmbhatt, Weijian Huang, Ting-Tung A. Chang, Anderson S. Peck, Clarissa Valdez, Vinayak P. Dravid, William L. Klein

This paper demonstrates that amyloid β oligomers (AβOs) are key drivers of Alzheimer's disease pathology and shows that AβO-selective antibodies can restore memory function and serve as diagnostic tools.

Frontiers in Neuroscience · Jan 3, 2022Peer-reviewedNeuroscience

Identification of amyloid beta oligomers in locus coeruleus (LC) neurons of Alzheimer's patients and their impact on LC oxidative stress, inhibitory neurotransmitter receptors and neuronal excitability

Louise Kelly, Mohsen Seifi, Ruolin Ma, Scott J. Mitchell, Uwe Rudolph, Kirsten L. Viola, William L. Klein, Jeremy J. Lambert, Jerome D. Swinny

Neuropathology and Applied Neurobiology · Oct 29, 2020Peer-reviewedNeuroscience

Succinylation Links Metabolic Reductions to Amyloid and Tau Pathology

Yun Yang, Vı́ctor Tapias, Diana M. Acosta, Hui Xu, Huan‐Lian Chen, Ruchika P. Bhawal, Elizabeth Anderson, Elena Ivanova, Hening Lin, Botir T. Sagdullaev, William L. Klein, Kirsten L. Viola, Sam Gandy, Vahram H. Haroutunian, M. Flint Beal, , Gary E. Gibson

This study identifies lysine succinylation as a post-translational modification linked to amyloid and tau pathology in Alzheimer's disease through human brain and mouse model analyses.

bioRxiv · Sep 16, 2019 · PreprintNeuroscience