ImmunologybioRxiv
Mitochondrial metabolism sustains CD8+ T cellmigration for an efficient infiltration into solid tumors
L. Simula, M. Fumagalli, L. Vimeux…·E. Donnadieu
This study shows mitochondrial metabolism, not glycolysis, is essential for CD8+ T cell migration in 3D tumor environments, and enhancing mitochondrial activity improves CAR T cell infiltration and tumor control.
DOI 10.1038/s41467-024-46377-7