Author

S. I. Mannering

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:comparative / phylogenetic analysis· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

A. M. Buckle· 1 shared A. Sutherland· 1 shared B. T. Porebski· 1 shared C. Elso· 1 shared C. F. Reboul· 1 shared D. Christ· 1 shared D. E. Hoke· 1 shared D. Elmlund· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiochemistry

A. M. Buckle

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2 papers

Recent·Most cited

Structure and dynamics of the autoantigen GAD65 in complex with the human autoimmune polyendocrine syndrome type 2-associated autoantibody b96.11

S. Stander, C. F. Reboul, S. N. Lee, D. Williams, P. G. Chandler, M. G. Costa, D. E. Hoke, J. D. Jimma, J. Fodor, G. Fenalti, S. I. Mannering, B. T. Porebski, P. Schofield, D. Christ, M. Buckle, , A. M. Buckle

This study characterizes the structure and dynamics of GAD65 and its interaction with autoantibody b96.11, revealing how intrinsic conformational flexibility drives autoantigenicity.

bioRxiv · Mar 18, 2024 · PreprintBiochemistry

Replacing murine insulin 1 with human insulin protects NOD mice from diabetes

C. Elso, N. Scott, L. Mariana, E. Masterman, A. Sutherland, H. Thomas, S. I. Mannering

This study replaces murine insulin 1 with human insulin in NOD mice, reducing diabetes incidence and showing protective effects against autoimmune responses.

bioRxiv · Oct 29, 2019Immunology