An engineered tumor organoid model reveals cellular identity and signaling trajectories underlying translocation RCC.
M. Ganpat, F. Morales-Rodriguez, N. Pham, P. Lijnzaad, T. de Souza, S. Derakhshan, A. Fumagalli, P. Zeller, A. Balwierz, D. Ayyildiz, M. M. van den Heuvel-Eibrink, R. R. de Krijger, A. van Oudenaarden, T. Margaritis, S. M. Chuva de Sousa Lopes, J. Drost
This study creates an engineered tumor organoid model of tRCC using SFPQ-TFE3 fusion expression, revealing epithelium-to-mesenchymal differentiation and Wnt signaling involvement in tumor transformation.
bioRxiv · Sep 1, 2023 · PreprintCancer Biology